Pedigrees were compiled for all reported HCM cases and then reviewed for ancestral commonalities. In some lines, HCM occurred in each generation, providing a clear path to identifying a potential ancestor. Other cases proved to be much more difficult either because of skipped generations or the lack of reporting by breeders.
HCM in Siberians seems to have multiple points of origin and several different strains (genetic types). Siberians are a young breed with excellent genetic diversity, although the vast majority are descended from St Petersburg or Moscow. Siberian Research was able to identify six potential points of origin where HCM could have entered the Siberian breed. Each began in distinct geographical regions, which made identification easier.
Note: Pedigree analysis is always subject to several types of flaws. The limited number of disclosed HCM cases may lead to incorrect conclusions. The presence of flawed or inaccurate pedigrees can be misleading. Even so, it is reasonable to be careful when breeding with lines that have shown HCM.
Ars Ussuri - (Moscow) - Revised 2013
About 60% of reported HCM cases have Moscow ancestry. Only one foundation cat was found in all the Moscow cases. The majority of reported cases came through his son, Amur Abakan, who was widely used in several breeding programs. Severe inbreeding with Amur Abakan has fixed HCM into a majority of the golden lines. This is of severe concern until such time as DNA testing becomes available.
Amur Abakan - Aldan Abakan - Verinea Sibiriada
Jelena Jesim iz Amu-Darja - (Germany)
A large number of HCM cases lead back to Jelena Jesim. She is present in roughly 40% of all documented cases of HCM, and the sudden death of Jelena Jesim has also been taken into consideration. Because there are no cases of HCM where an ancestor of Jelena Jesim is present and Jelena is not, it is reasonable to assume that the pedigree may have an error or the mutation may have occurred in her generation. Only the three offspring listed have shown HCM in their lines.
Snowknight Casylin - Snowknight Destiny - Snowknight Derringer
Saranka - (St. Petersburg)
Siberians from the Saranka lines show changes in the septal wall and papillary muscles before affecting the left ventricular wall. The type of HCM in these cats were grouped to find a common ancestor, and Saranka appears to be the only possible point of origin. The earliest Russian pedigrees do not show ancestors for Saranka, and no ancestors listed on her later pedigrees have commonality with any HCM cases.
Zemfira Amurskaya / Ralmond Marcell - (St. Petersburg)
Jenisey Silva Line was diagnosed with severe HCM. Three siblings from an earlier mating of Ralmond Marcell and Zemfira were imported to Sweden in 2000. All three (Berta, Betsi, Brus) died at an early age, but we do not have permission to reveal the nature of the deaths.
Anfisa II - (St. Petersburg) - Revised 2013
Three early deaths were reported on this line. Yustas of Croshka and two other direct offspring were imported to the US in the early 90‘s. Multiple offspring from their litters were also found to have HCM, though the early cases occurred prior to breeders being aware of HCM, when ultrasound and necropsies were uncommon. Two of these lines are no long in breeding, however four new cases of heart disease in these lines were documented in 2009. Several major lines in the USA are at risk, we do not know if these lines exist outside of the USA.
Arahmis - Iris Aralia - (possibly others)
Zanadu Siberians - (USA)
One prominent line in the US has reported multiple deaths, and there are quite a few echocardiograms confirming heart disease. Zanadu Siberians graciously released all records of HCM that occurred in their cattery, which can be found in the open record section of the SRI website. The first case of HCM reported in the USA was Windrifter Cholchinay of BirchGrove, a direct descendant from this lineage.
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